Technology Archives - Carina Biotech

How small proteins called chemokines could be the answer to getting cancer-busting CAR-T cells directly into solid tumours
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How small proteins called chemokines could be the answer to getting cancer-busting CAR-T cells directly into solid tumours

How small proteins called chemokines could be the answer to getting cancer-busting CAR-T cells directly into solid tumours

Kathy Sharrard2023-05-05T11:44:58+09:30July 6th, 2022|Science, Technology|

Figure 1. CAR-T cells versus the solid tumor microenvironment (from Foeng et al 2022). ____________ It is now no secret that chimeric antigen receptor (CAR)-T cell therapy has produced remarkable

#1 Lack of ideal solid cancer antigen targets

Kathy Sharrard2018-09-10T11:54:56+09:30August 18th, 2018|Technology|

The current CAR-T market is driven largely by CAR-T cells targeted against blood cancers and at only one antigen (CD19). Anti-CD19 CAR-T cells have consistently demonstrated high anti-tumour efficacy in

#2 Limited access of CAR-T cells to solid tumours

Kathy Sharrard2018-09-10T11:56:01+09:30August 18th, 2018|Technology|

So far it has proven a challenge to deliver clinically effective doses of CAR-T cells to solid tumours or resection (after surgery) sites. One of the issues to overcome is