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Studies in the early 1980s demonstrated that intravenous injection of T cells expanded in IL-2 could treat bulky subcutaneous lymphomas, and the administration of IL-2 after cell transfer increased T

In 1972 scientists describe the T cell growth factor IL-2 (interleukin-2), paving the way to grow T cells ex vivo. The direct application of high doses of IL-2 inhibited tumour growth in

In the 1960s, early attempts to use T cells to treat transplanted mice tumours were unsuccessful due to an inability to multiply and manipulate the T cells in culture.