Professor Simon Barry

Senior Research Fellow, University of Adelaide

Chief Medical Scientist, Women’s & Children’s Hospital, Adelaide

Professor Simon Barry is an expert in T cell biology and the co-inventor of Carina’s lead CAR-T cell. He is co-appointed to the Women’s & Children’s Hospital, Adelaide, and the University of Adelaide. Simon’s background in molecular biology and gene discovery led him to use unbiased genome-wide discovery platforms as a way to identify the key genes and pathways in a cell. His research team was the first in the world to use genome-wide approaches to discover the key targets of FOXP3 in human regulatory T cells (Tregs), and to validate their biological importance in vitro and in vivo. Simon’s group discovered a key target of FOXP3, SATB1, which is regulated to maintain Treg function. Simon was approached by Carina’s now MD Dr Justin Coombs to develop a CAR-T cell targeted to a specific marker on cancer cells. His lab at the Women’s & Children’s Hospital achieved this, and Carina Biotech was formed. Professor Barry is published in Nature Cell Biology and Nature Immunology, and has over 5600 citations in the scientific literature.
Professor Simon Barry headshot